Modifying Methoxycarbonyl Etomidate’s Inter-Ester Spacer Optimizes In Vitro Metabolic Stability and In Vivo Hypnotic Potency and Duration of Action

Por Husain, S. Shaukat, Pejo, Ervin, Ge, Rile, Raines, Douglas E.
Publicado em 2012

Sedative-Hypnotic Binding to 11β-Hydroxylase

Por Pejo, Ervin, Zhou, Xiaojuan, Husain, S. Shaukat, Raines, Douglas E.
Publicado no Anesthesiology (2016)

Multiple Transmembrane Binding Sites for p-Trifluoromethyldiazirinyl-etomidate, a Photoreactive Torpedo Nicotinic Acetylcholine Receptor Allosteric Inhibitor

Por Hamouda, Ayman K., Stewart, Deirdre S., Husain, S. Shaukat, Cohen, Jonathan B.
Publicado em 2011

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for TDBzl-etomidate, a Photoreactive Positive Allosteric Effector

Por Nirthanan, Selvanayagam, Garcia, Galo, Chiara, David C., Husain, S. Shaukat, Cohen, Jonathan B.
Publicado em 2008

Electroencephalographic and Hypnotic Recoveries Following Brief and Prolonged Infusions of Etomidate and Optimized Soft Etomidate Analogs

Por Ge, Rile, Pejo, Ervin, Husain, S. Shaukat, Cotten, Joseph F., Raines, Douglas E.
Publicado em 2012

Analogues of Etomidate: Modifications Around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

Por Pejo, Ervin, Santer, Peter, Jeffrey, Spencer, Gallin, Hilary, Husain, S. Shaukat, Raines, Douglas E.
Publicado em 2014

GABA(A) Receptor Modulation by Etomidate Analogues

Por Pejo, Ervin, Santer, Peter, Wang, Lei, Dershwitz, Philip, Husain, S. Shaukat, Raines, Douglas E.
Publicado no Anesthesiology (2016)

Electroencephalographic Recovery, Hypnotic Emergence, and the Effects of Metabolite Following Continuous Infusions of a Rapidly Metabolized Etomidate Analog in Rats

Por Pejo, Ervin, Ge, Rile, Banacos, Natalie, Cotten, Joseph F., Husain, S. Shaukat, Raines, Douglas E.
Publicado em 2012

Pharmacological Studies of Methoxycarbonyl Etomidate's Carboxylic Acid Metabolite

Por Ge, Ri Le, Pejo, Ervin, Haburcak, Marian, Husain, S. Shaukat, Forman, Stuart A., Raines, Douglas E.
Publicado em 2011

Closed-loop Continuous Infusions of Etomidate and Etomidate Analogs in Rats: A Comparative Study of Dosing and the Impact on Adrenocortical Function

Por Cotten, Joseph F., Le Ge, Ri, Banacos, Natalie, Pejo, Ervin, Husain, S. Shaukat, Williams, James H., Raines, Douglas E.
Publicado em 2011

Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor by [(3)H]Azietomidate, an Open-State Inhibitor

Por Chiara, David C., Hong, Filbert H., Arevalo, Enrique, Husain, S. Shaukat, Miller, Keith W., Forman, Stuart A., Cohen, Jonathan B.
Publicado em 2009

The Location and Nature of General Anesthetic Binding Sites on the Active Conformation of Firefly Luciferase; A Time Resolved Photolabeling Study

Por Shanmugasundararaj, Sivananthaperumal, Lehle, Simon, Yamodo, Herve I., Husain, S. Shaukat, Tseng, Claire, Nguyen, Khanh, Addona, George H., Miller, Keith W.
Publicado em 2012

Methoxycarbonyl-etomidate: A Novel Rapidly Metabolized and Ultra-Short Acting Etomidate Analogue That Does Not Produce Prolonged Adrenocortical Suppression

Por Cotten, Joseph F., Husain, S. Shaukat, Forman, Stuart A., Miller, Keith W., Kelly, Elizabeth W., Nguyen, Hieu H., Raines, Douglas E.
Publicado em 2009

Carboetomidate: A Pyrrole Analogue of Etomidate Designed Not To Suppress Adrenocortical Function

Por Cotten, Joseph F., Forman, Stuart A., Laha, Joydev K., Cuny, Gregory D., Husain, S. Shaukat, Miller, Keith W., Nguyen, Hieu H., Kelly, Elizabeth W., Stewart, Deirdre, Liu, Aiping, Raines, Douglas E.
Publicado em 2010

p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels

Por Husain, S. Shaukat, Stewart, Deirdre, Desai, Rooma, Hamouda, Ayman K., Li, S. Guo-Dong, Kelly, Elizabeth, Dostalova, Zuzana, Zhou, Xiaojuan, Cotten, Joseph F., Raines, Douglas A., Olsen, Richard W., Cohen, Jonathan B., Forman, Stuart A., Miller, Keith W.
Publicado em 2010