γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity

Por Desai, Rooma, Ruesch, Dirk, Forman, Stuart A.
Publicado em 2009

The Pyrrole Etomidate Analog Carboetomidate Potently Inhibits Human 5-HT(3A) Receptor Function: Comparisons with Etomidate and Potential Implications for Emetogenesis

Por Desai, Rooma, Miller, Keith W., Raines, Douglas E.
Publicado em 2013

State-Dependent Etomidate Occupancy of Its Allosteric Agonist Sites Measured in a Cysteine-Substituted GABA(A) Receptor

Por Stewart, Deirdre S., Hotta, Mayo, Desai, Rooma, Forman, Stuart A.
Publicado em 2013

Tryptophan Mutations at Azi-Etomidate Photo-Incorporation Sites on α(1) or β(2) Subunits Enhance GABA(A) Receptor Gating and Reduce Etomidate Modulation

Por Stewart, Deirdre, Desai, Rooma, Cheng, Qi, Liu, Aiping, Forman, Stuart A.
Publicado em 2008

Protein Kinase C Modulates Inactivation of Kv3.3 Channels

Por Desai, Rooma, Kronengold, Jack, Mei, Jianfeng, Forman, Stuart A., Kaczmarek, Leonard K.
Publicado em 2008

Extracellular K(+) and Opening of Voltage-Gated Potassium Channels Activate T Cell Integrin Function: Physical and Functional Association between Kv1.3 Channels and β1 Integrins

Por Levite, Mia, Cahalon, Liora, Peretz, Asher, Hershkoviz, Rami, Sobko, Alex, Ariel, Amiram, Desai, Rooma, Attali, Bernard, Lider, Ofer
Publicado em 2000

Cysteine Substitutions Define Etomidate Binding and Gating Linkages in the α-M1 Domain of γ-Aminobutyric Acid Type A (GABA(A)) Receptors

Por Stewart, Deirdre S., Hotta, Mayo, Li, Guo-dong, Desai, Rooma, Chiara, David C., Olsen, Richard W., Forman, Stuart A.
Publicado em 2013

Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state

Por Dostalova, Zuzana, Zhou, Xiaojuan, Liu, Aiping, Zhang, Xi, Zhang, Yinghui, Desai, Rooma, Forman, Stuart A, Miller, Keith W
Publicado em 2014

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABA(A)) Receptor by Binding to a Site in the Transmembrane Domain at the γ(+)-β(−) Interface...

Por Jayakar, Selwyn S., Zhou, Xiaojuan, Savechenkov, Pavel Y., Chiara, David C., Desai, Rooma, Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Publicado no J Biol Chem (2015)

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α(1)β(3)γ(2L) GABA(A) receptor account for their in vivo effects

Por Desai, Rooma, Savechenkov, Pavel Y., Zolkowska, Dorota, Ge, Ri Le, Rogawski, Michael A., Bruzik, Karol S., Forman, Stuart A., Raines, Douglas E., Miller, Keith W.
Publicado no J Physiol (2015)

High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABA(A) and serotonin receptors

Por Dostalova, Zuzana, Liu, Aiping, Zhou, Xiaojuan, Farmer, Sarah L, Krenzel, Eileen S, Arevalo, Enrique, Desai, Rooma, Feinberg-Zadek, Paula L, Davies, Paul A, Yamodo, Innocent H, Forman, Stuart A, Miller, Keith W
Publicado em 2010

p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels

Por Husain, S. Shaukat, Stewart, Deirdre, Desai, Rooma, Hamouda, Ayman K., Li, S. Guo-Dong, Kelly, Elizabeth, Dostalova, Zuzana, Zhou, Xiaojuan, Cotten, Joseph F., Raines, Douglas A., Olsen, Richard W., Cohen, Jonathan B., Forman, Stuart A., Miller, Keith W.
Publicado em 2010

Kv3.3 channels bind Hax-1 and Arp2/3 to assemble a stable local actin network that regulates channel gating

Por Zhang, Yalan, Zhang, Xiao-Feng, Fleming, Matthew R., Amiri, Anahita, El-Hassar, Lynda, Surguchev, Alexei A., Hyland, Callen, Jenkins, David P., Desai, Rooma, Brown, Maile R., Gazula, Valeswara-Rao, Waters, Michael F., Large, Charles H., Horvath, Tamas L., Navaratnam, Dhasakumar, Vaccarino, Flora M., Forscher, Paul, Kaczmarek, Leonard K.
Publicado no Cell (2016)