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State-Dependent Etomidate Occupancy of Its Allosteric Agonist Sites Measured in a Cysteine-Substituted GABA(A) Receptor

A central axiom of ligand-receptor theory is that agonists bind more tightly to active than to inactive receptors. However, measuring agonist affinity in inactive receptors is confounded by concomitant activation. We identified a cysteine substituted mutant γ-aminobutyric acid type A (GABA(A)) recep...

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Detaylı Bibliyografya
Asıl Yazarlar: Stewart, Deirdre S., Hotta, Mayo, Desai, Rooma, Forman, Stuart A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657098/
https://ncbi.nlm.nih.gov/pubmed/23525330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.084558
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