Chargement en cours...

State-Dependent Etomidate Occupancy of Its Allosteric Agonist Sites Measured in a Cysteine-Substituted GABA(A) Receptor

A central axiom of ligand-receptor theory is that agonists bind more tightly to active than to inactive receptors. However, measuring agonist affinity in inactive receptors is confounded by concomitant activation. We identified a cysteine substituted mutant γ-aminobutyric acid type A (GABA(A)) recep...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Stewart, Deirdre S., Hotta, Mayo, Desai, Rooma, Forman, Stuart A.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657098/
https://ncbi.nlm.nih.gov/pubmed/23525330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.084558
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!