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The Two Etomidate Sites in α1β2γ2 GABA(A) Receptors Contribute Equally and Non-cooperatively to Modulation of Channel Gating
BACKGROUND: Etomidate is a potent hypnotic agent that acts via γ-aminobutyric acid type A (GABA(A)) receptors. Evidence supports the presence of two etomidate sites per GABA(A) receptor, and current models assume that each site contributes equally and non-cooperatively to drug effects. These assumpt...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366439/ https://ncbi.nlm.nih.gov/pubmed/22531336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3182567df3 |
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