Cysteine Substitutions Define Etomidate Binding and Gating Linkages in the α-M1 Domain of γ-Aminobutyric Acid Type A (GABA(A)) Receptors

Etomidate is a potent general anesthetic that acts as an allosteric co-agonist at GABA(A) receptors. Photoreactive etomidate derivatives labeled αMet-236 in transmembrane domain M1, which structural models locate in the β+/α- subunit interface. Other nearby residues may also contribute to etomidate...

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Detalhes bibliográficos
Main Authors: Stewart, Deirdre S., Hotta, Mayo, Li, Guo-dong, Desai, Rooma, Chiara, David C., Olsen, Richard W., Forman, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798502/
https://ncbi.nlm.nih.gov/pubmed/24009076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.494583
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