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Tryptophan Mutations at Azi-Etomidate Photo-Incorporation Sites on α(1) or β(2) Subunits Enhance GABA(A) Receptor Gating and Reduce Etomidate Modulation
The potent general anesthetic etomidate produces its effects by enhancing GABA(A) receptor activation. Its photolabel analog [(3)H]-azi-etomidate labels residues within transmembrane domains on α and β subunits: αM236 and βM286. We hypothesized that these methionines contribute to etomidate sites fo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596762/ https://ncbi.nlm.nih.gov/pubmed/18805938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.050500 |
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