Tryptophan Mutations at Azi-Etomidate Photo-Incorporation Sites on α(1) or β(2) Subunits Enhance GABA(A) Receptor Gating and Reduce Etomidate Modulation

The potent general anesthetic etomidate produces its effects by enhancing GABA(A) receptor activation. Its photolabel analog [(3)H]-azi-etomidate labels residues within transmembrane domains on α and β subunits: αM236 and βM286. We hypothesized that these methionines contribute to etomidate sites fo...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Stewart, Deirdre, Desai, Rooma, Cheng, Qi, Liu, Aiping, Forman, Stuart A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596762/
https://ncbi.nlm.nih.gov/pubmed/18805938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.050500
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky