Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA(A) Receptors

GABA(A) receptors can be directly activated and potentiated by the intravenous anesthetic propofol. Previous photolabeling, modeling, and functional data have identified two binding domains through which propofol acts on the GABA(A) receptor. These domains are defined by the β(M286) residue at the β...

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Vydáno v:Mol Pharmacol
Hlavní autoři: Shin, Daniel J., Germann, Allison L., Johnson, Alexander D., Forman, Stuart A., Steinbach, Joe Henry, Akk, Gustav
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772375/
https://ncbi.nlm.nih.gov/pubmed/29192122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110403
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