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Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA(A) Receptors
GABA(A) receptors can be directly activated and potentiated by the intravenous anesthetic propofol. Previous photolabeling, modeling, and functional data have identified two binding domains through which propofol acts on the GABA(A) receptor. These domains are defined by the β(M286) residue at the β...
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| Publicat a: | Mol Pharmacol |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5772375/ https://ncbi.nlm.nih.gov/pubmed/29192122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110403 |
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