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GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC(50) and Basal Activity

The concerted transition model for multimeric proteins is a simple formulation for analyzing the behavior of transmitter-gated ion channels. We used the model to examine the relationship between the EC(50) for activation of the GABA type A (GABA(A)) receptor by the transmitter GABA and basal activit...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Akk, Gustav, Shin, Daniel J., Germann, Allison L., Steinbach, Joe Henry
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749490/
https://ncbi.nlm.nih.gov/pubmed/29150461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110569
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