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Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA(A) Receptor: Relating Occupancy to State Functions

Muscimol is a psychoactive isoxazole derived from the mushroom Amanita muscaria and a potent orthosteric agonist of the GABA(A) receptor. The binding of [(3)H]muscimol has been used to evaluate the distribution of GABA(A) receptors in the brain, and studies of modulation of [(3)H]muscimol binding by...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Pharmacol
Prif Awduron: Akk, Gustav, Germann, Allison L., Sugasawa, Yusuke, Pierce, Spencer R., Evers, Alex S., Steinbach, Joe Henry
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472144/
https://ncbi.nlm.nih.gov/pubmed/32873746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.120.000066
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