Reduced Activation of the Synaptic-Type GABA(A) Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization

Synaptic GABA(A) receptors are alternately exposed to short pulses of a high, millimolar concentration of GABA and prolonged periods of low, micromolar concentration of the transmitter. Prior work has indicated that exposure to micromolar concentrations of GABA can both activate the postsynaptic rec...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Pierce, Spencer R., Germann, Allison L., Evers, Alex S., Steinbach, Joe Henry, Akk, Gustav
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Accelerated Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673486/
https://ncbi.nlm.nih.gov/pubmed/32978327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000088
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