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Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABA(A) Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone
Prior work employing functional analysis, photolabeling, and X-ray crystallography have identified three distinct binding sites for potentiating steroids in the heteromeric GABA(A) receptor. The sites are located in the membrane-spanning domains of the receptor at the β-α subunit interface (site I)...
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| Udgivet i: | Mol Pharmacol |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8256884/ https://ncbi.nlm.nih.gov/pubmed/33958479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.121.000268 |
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