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Site-specific effects of neurosteroids on GABA(A) receptor activation and desensitization

This study examines how site-specific binding to three identified neurosteroid-binding sites in the α(1)β(3) GABA(A) receptor (GABA(A)R) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but not its inhibitory 3β-epimer epi-allopregnano...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Sugasawa, Yusuke, Cheng, Wayland WL, Bracamontes, John R, Chen, Zi-Wei, Wang, Lei, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Krishnan, Kathiresan, Reichert, David E, Covey, Douglas F, Akk, Gustav, Evers, Alex S
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7532004/
https://ncbi.nlm.nih.gov/pubmed/32955433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55331
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