The Molecular Determinants of Neurosteroid Binding in the GABA(A) Receptor

Neurosteroids positively modulate GABA-A receptor (GABA(A)R) channel activity by binding to a transmembrane domain intersubunit site. Understanding the interactions in this site that determine neurosteroid binding and its effect is essential for the design of neurosteroid-based therapeutics. Using p...

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Gepubliceerd in:J Steroid Biochem Mol Biol
Hoofdauteurs: Sugasawa, Yusuke, Bracamontes, John R., Krishnan, Kathiresan, Covey, Douglas F., Reichert, David E., Akk, Gustav, Chen, Qiang, Tang, Pei, Evers, Alex S., Cheng, Wayland W. L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708749/
https://ncbi.nlm.nih.gov/pubmed/31150831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2019.105383
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