Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABA(A) Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone

Prior work employing functional analysis, photolabeling, and X-ray crystallography have identified three distinct binding sites for potentiating steroids in the heteromeric GABA(A) receptor. The sites are located in the membrane-spanning domains of the receptor at the β-α subunit interface (site I)...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Germann, Allison L., Pierce, Spencer R., Tateiwa, Hiroki, Sugasawa, Yusuke, Reichert, David E., Evers, Alex S., Steinbach, Joe Henry, Akk, Gustav
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256884/
https://ncbi.nlm.nih.gov/pubmed/33958479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.121.000268
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