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Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA(A) Receptors

GABA(A) receptors can be directly activated and potentiated by the intravenous anesthetic propofol. Previous photolabeling, modeling, and functional data have identified two binding domains through which propofol acts on the GABA(A) receptor. These domains are defined by the β(M286) residue at the β...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Shin, Daniel J., Germann, Allison L., Johnson, Alexander D., Forman, Stuart A., Steinbach, Joe Henry, Akk, Gustav
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772375/
https://ncbi.nlm.nih.gov/pubmed/29192122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110403
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