Kv3.3 channels bind Hax-1 and Arp2/3 to assemble a stable local actin network that regulates channel gating

Mutations in the Kv3.3 potassium channel (KCNC3) cause cerebellar neurodegeneration and impair auditory processing. The cytoplasmic C-terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate actin nucleation through Arp2/3. We found that Kv3.3 recruits Arp2/3 to the plasm...

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Publicado no:Cell
Main Authors: Zhang, Yalan, Zhang, Xiao-Feng, Fleming, Matthew R., Amiri, Anahita, El-Hassar, Lynda, Surguchev, Alexei A., Hyland, Callen, Jenkins, David P., Desai, Rooma, Brown, Maile R., Gazula, Valeswara-Rao, Waters, Michael F., Large, Charles H., Horvath, Tamas L., Navaratnam, Dhasakumar, Vaccarino, Flora M., Forscher, Paul, Kaczmarek, Leonard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826296/
https://ncbi.nlm.nih.gov/pubmed/26997484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.009
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