Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

In humans, absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome (FXS), the most common inherited form of intellectual disability. Here we report through biochemical and electrophysiological studies that FMRP binds the C-terminus of the Slack s...

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Detalhes bibliográficos
Main Authors: Brown, Maile R., Kronengold, Jack, Gazula, Valeswara-Rao, Chen, Yi, Strumbos, John G., Sigworth, Fred J., Navaratnam, Dhasakumar, Kaczmarek, Leonard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893252/
https://ncbi.nlm.nih.gov/pubmed/20512134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2563
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