Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α(1)β(3)γ(2L) GABA(A) receptor account for their in vivo effects

KEY POINTS: Most barbiturates are anaesthetics but unexpectedly a few are convulsants whose mechanism of action is poorly understood. We synthesized and characterized a novel pair of chiral barbiturates that are capable of photolabelling their binding sites on GABA(A) receptors. In mice the S‐enanti...

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Publicado en:J Physiol
Autores principales: Desai, Rooma, Savechenkov, Pavel Y., Zolkowska, Dorota, Ge, Ri Le, Rogawski, Michael A., Bruzik, Karol S., Forman, Stuart A., Raines, Douglas E., Miller, Keith W.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2015
Materias:
Neuroscience ‐ Cellular/Molecular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650410/
https://ncbi.nlm.nih.gov/pubmed/26378885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP270971
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