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Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α(1)β(3)γ(2L) GABA(A) receptor account for their in vivo effects
KEY POINTS: Most barbiturates are anaesthetics but unexpectedly a few are convulsants whose mechanism of action is poorly understood. We synthesized and characterized a novel pair of chiral barbiturates that are capable of photolabelling their binding sites on GABA(A) receptors. In mice the S‐enanti...
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| Publicado en: | J Physiol |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4650410/ https://ncbi.nlm.nih.gov/pubmed/26378885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP270971 |
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