Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic

We synthesized 5-allyl-1-methyl-5-(m-trifluoromethyl-diazirynylphenyl)barbituric acid (14), a trifluoromethyldiazirine-containing derivative of general anesthetic mephobarbital, separated the racemic mixture into enantiomers by chiral chromatography, and determined the configuration of the (+)-enant...

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Detalhes bibliográficos
Main Authors: Savechenkov, Pavel Y., Zhang, Xi, Chiara, David C., Stewart, Deirdre S., Ge, Rile, Zhou, Xiaojuan, Raines, Douglas E., Cohen, Jonathan B., Forman, Stuart A., Miller, Keith W., Bruzik, Karol S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717557/
https://ncbi.nlm.nih.gov/pubmed/22734650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300631e
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