A Potent Photoreactive General Anesthetic with Novel Binding Site Selectivity for GABA(A) Receptors.

The pentameric γ-aminobutyric acid type A receptors (GABA(A)Rs) are the major inhibitory ligand-gated ion channels in the central nervous system. They mediate diverse physiological functions, mutations in them are associated with mental disorders and they are the target of many drugs such as general...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Eur J Med Chem
Prif Awduron: Shalabi, Abdelrahman R., Yu, Zhiyi, Zhou, Xiaojuan, Jounaidi, Youssef, Chen, Hanwen, Dai, Jiajia, Kent, Daniel E., Feng, Hua-Jun, Forman, Stuart A., Cohen, Jonathan B, Bruzik, Karol S., Miller, Keith W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342775/
https://ncbi.nlm.nih.gov/pubmed/32247113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112261
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