A Potent Photoreactive General Anesthetic with Novel Binding Site Selectivity for GABA(A) Receptors.

The pentameric γ-aminobutyric acid type A receptors (GABA(A)Rs) are the major inhibitory ligand-gated ion channels in the central nervous system. They mediate diverse physiological functions, mutations in them are associated with mental disorders and they are the target of many drugs such as general...

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Publicat a:Eur J Med Chem
Autors principals: Shalabi, Abdelrahman R., Yu, Zhiyi, Zhou, Xiaojuan, Jounaidi, Youssef, Chen, Hanwen, Dai, Jiajia, Kent, Daniel E., Feng, Hua-Jun, Forman, Stuart A., Cohen, Jonathan B, Bruzik, Karol S., Miller, Keith W.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342775/
https://ncbi.nlm.nih.gov/pubmed/32247113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112261
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