A Potent Photoreactive General Anesthetic with Novel Binding Site Selectivity for GABA(A) Receptors.

The pentameric γ-aminobutyric acid type A receptors (GABA(A)Rs) are the major inhibitory ligand-gated ion channels in the central nervous system. They mediate diverse physiological functions, mutations in them are associated with mental disorders and they are the target of many drugs such as general...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Shalabi, Abdelrahman R., Yu, Zhiyi, Zhou, Xiaojuan, Jounaidi, Youssef, Chen, Hanwen, Dai, Jiajia, Kent, Daniel E., Feng, Hua-Jun, Forman, Stuart A., Cohen, Jonathan B, Bruzik, Karol S., Miller, Keith W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342775/
https://ncbi.nlm.nih.gov/pubmed/32247113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112261
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