General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABA(A)Rs)

Extrasynaptic γ-aminobutyric acid type A receptors (GABA(A)Rs),which contribute generalized inhibitory tone to the mammalian brain, are major targets for general anesthetics. To identify anesthetic binding sites in an extrasynaptic GABA(A)R, we photolabeled human α4β3δ GABA(A)Rs purified in detergen...

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Publicado en:J Biol Chem
Autores principales: Chiara, David C., Jounaidi, Youssef, Zhou, Xiaojuan, Savechenkov, Pavel Y., Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159512/
https://ncbi.nlm.nih.gov/pubmed/27821594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753335
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