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General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABA(A)Rs)
Extrasynaptic γ-aminobutyric acid type A receptors (GABA(A)Rs),which contribute generalized inhibitory tone to the mammalian brain, are major targets for general anesthetics. To identify anesthetic binding sites in an extrasynaptic GABA(A)R, we photolabeled human α4β3δ GABA(A)Rs purified in detergen...
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| Publicado en: | J Biol Chem |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5159512/ https://ncbi.nlm.nih.gov/pubmed/27821594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753335 |
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