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General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABA(A)Rs)

Extrasynaptic γ-aminobutyric acid type A receptors (GABA(A)Rs),which contribute generalized inhibitory tone to the mammalian brain, are major targets for general anesthetics. To identify anesthetic binding sites in an extrasynaptic GABA(A)R, we photolabeled human α4β3δ GABA(A)Rs purified in detergen...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Chiara, David C., Jounaidi, Youssef, Zhou, Xiaojuan, Savechenkov, Pavel Y., Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159512/
https://ncbi.nlm.nih.gov/pubmed/27821594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753335
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