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General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABA(A)Rs)

Extrasynaptic γ-aminobutyric acid type A receptors (GABA(A)Rs),which contribute generalized inhibitory tone to the mammalian brain, are major targets for general anesthetics. To identify anesthetic binding sites in an extrasynaptic GABA(A)R, we photolabeled human α4β3δ GABA(A)Rs purified in detergen...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Chiara, David C., Jounaidi, Youssef, Zhou, Xiaojuan, Savechenkov, Pavel Y., Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159512/
https://ncbi.nlm.nih.gov/pubmed/27821594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753335
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