Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABA(A)R) Identified Using a Photoreactive Propofol Analog

Propofol acts as a positive allosteric modulator of γ-aminobutyric acid type A receptors (GABA(A)Rs), an interaction necessary for its anesthetic potency in vivo as a general anesthetic. Identifying the location of propofol-binding sites is necessary to understand its mechanism of GABA(A)R modulatio...

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Bibliographic Details
Main Authors: Jayakar, Selwyn S., Zhou, Xiaojuan, Chiara, David C., Dostalova, Zuzana, Savechenkov, Pavel Y., Bruzik, Karol S., Dailey, William P., Miller, Keith W., Eckenhoff, Roderic G., Cohen, Jonathan B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183786/
https://ncbi.nlm.nih.gov/pubmed/25086038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581728
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