Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABA(A)) Receptor

GABA type A receptors (GABA(A)R), the brain's major inhibitory neurotransmitter receptors, are the targets for many general anesthetics, including volatile anesthetics, etomidate, propofol, and barbiturates. How such structurally diverse agents can act similarly as positive allosteric modulator...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Chiara, David C., Jayakar, Selwyn S., Zhou, Xiaojuan, Zhang, Xi, Savechenkov, Pavel Y., Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2013
Aiheet:
Neurobiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707639/
https://ncbi.nlm.nih.gov/pubmed/23677991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479725
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