Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABA(A)) Receptor

GABA type A receptors (GABA(A)R), the brain's major inhibitory neurotransmitter receptors, are the targets for many general anesthetics, including volatile anesthetics, etomidate, propofol, and barbiturates. How such structurally diverse agents can act similarly as positive allosteric modulator...

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Hlavní autoři: Chiara, David C., Jayakar, Selwyn S., Zhou, Xiaojuan, Zhang, Xi, Savechenkov, Pavel Y., Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707639/
https://ncbi.nlm.nih.gov/pubmed/23677991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479725
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