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Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABA(A)R Transmembrane Domain
GABA(A) receptors (GABA(A)Rs) are targets for important classes of clinical agents (e.g., anxiolytics, anticonvulsants, and general anesthetics) that act as positive allosteric modulators (PAMs). Previously, using photoreactive analogs of etomidate ([(3)H]azietomidate) and mephobarbital [[(3)H]1-met...
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| Publicat a: | Mol Pharmacol |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505378/ https://ncbi.nlm.nih.gov/pubmed/30952799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.114975 |
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