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Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABA(A)R Transmembrane Domain

GABA(A) receptors (GABA(A)Rs) are targets for important classes of clinical agents (e.g., anxiolytics, anticonvulsants, and general anesthetics) that act as positive allosteric modulators (PAMs). Previously, using photoreactive analogs of etomidate ([(3)H]azietomidate) and mephobarbital [[(3)H]1-met...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Pharmacol
Prif Awduron: Jayakar, Selwyn S., Zhou, Xiaojuan, Chiara, David C., Jarava-Barrera, Carlos, Savechenkov, Pavel Y., Bruzik, Karol S., Tortosa, Mariola, Miller, Keith W., Cohen, Jonathan B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505378/
https://ncbi.nlm.nih.gov/pubmed/30952799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.114975
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