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Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABA(A)) Receptor by Binding to a Site in the Transmembrane Domain at the γ(+)-β(−) Interface

In the process of developing safer general anesthetics, isomers of anesthetic ethers and barbiturates have been discovered that act as convulsants and inhibitors of γ-aminobutyric acid type A receptors (GABA(A)Rs) rather than potentiators. It is unknown whether these convulsants act as negative allo...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Jayakar, Selwyn S., Zhou, Xiaojuan, Savechenkov, Pavel Y., Chiara, David C., Desai, Rooma, Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645599/
https://ncbi.nlm.nih.gov/pubmed/26229099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672006
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