Loading...

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABA(A)) Receptor by Binding to a Site in the Transmembrane Domain at the γ(+)-β(−) Interface

In the process of developing safer general anesthetics, isomers of anesthetic ethers and barbiturates have been discovered that act as convulsants and inhibitors of γ-aminobutyric acid type A receptors (GABA(A)Rs) rather than potentiators. It is unknown whether these convulsants act as negative allo...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Jayakar, Selwyn S., Zhou, Xiaojuan, Savechenkov, Pavel Y., Chiara, David C., Desai, Rooma, Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645599/
https://ncbi.nlm.nih.gov/pubmed/26229099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672006
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!