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Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABA(A)R Transmembrane Domain
GABA(A) receptors (GABA(A)Rs) are targets for important classes of clinical agents (e.g., anxiolytics, anticonvulsants, and general anesthetics) that act as positive allosteric modulators (PAMs). Previously, using photoreactive analogs of etomidate ([(3)H]azietomidate) and mephobarbital [[(3)H]1-met...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Pharmacol |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505378/ https://ncbi.nlm.nih.gov/pubmed/30952799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.114975 |
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