Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABA(A)R) Identified Using a Photoreactive Propofol Analog

Propofol acts as a positive allosteric modulator of γ-aminobutyric acid type A receptors (GABA(A)Rs), an interaction necessary for its anesthetic potency in vivo as a general anesthetic. Identifying the location of propofol-binding sites is necessary to understand its mechanism of GABA(A)R modulatio...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Jayakar, Selwyn S., Zhou, Xiaojuan, Chiara, David C., Dostalova, Zuzana, Savechenkov, Pavel Y., Bruzik, Karol S., Dailey, William P., Miller, Keith W., Eckenhoff, Roderic G., Cohen, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183786/
https://ncbi.nlm.nih.gov/pubmed/25086038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581728
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares