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General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABA(A)Rs)

Extrasynaptic γ-aminobutyric acid type A receptors (GABA(A)Rs),which contribute generalized inhibitory tone to the mammalian brain, are major targets for general anesthetics. To identify anesthetic binding sites in an extrasynaptic GABA(A)R, we photolabeled human α4β3δ GABA(A)Rs purified in detergen...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Chiara, David C., Jounaidi, Youssef, Zhou, Xiaojuan, Savechenkov, Pavel Y., Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159512/
https://ncbi.nlm.nih.gov/pubmed/27821594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753335
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