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A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor
Many neuroactive steroids potently and allosterically modulate pentameric ligand-gated ion channels, including GABA(A) receptors (GABA(A)R) and nicotinic acetylcholine receptors (nAChRs). Allopregnanolone and its synthetic analog alphaxalone are GABA(A)R-positive allosteric modulators (PAMs), wherea...
Uloženo v:
| Vydáno v: | J Biol Chem |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6514614/ https://ncbi.nlm.nih.gov/pubmed/30923128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007172 |
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