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A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor

Many neuroactive steroids potently and allosterically modulate pentameric ligand-gated ion channels, including GABA(A) receptors (GABA(A)R) and nicotinic acetylcholine receptors (nAChRs). Allopregnanolone and its synthetic analog alphaxalone are GABA(A)R-positive allosteric modulators (PAMs), wherea...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yu, Zhiyi, Chiara, David. C., Savechenkov, Pavel Y., Bruzik, Karol S., Cohen, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514614/
https://ncbi.nlm.nih.gov/pubmed/30923128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007172
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