Modifying Methoxycarbonyl Etomidate’s Inter-Ester Spacer Optimizes In Vitro Metabolic Stability and In Vivo Hypnotic Potency and Duration of Action

Por Husain, S. Shaukat, Pejo, Ervin, Ge, Rile, Raines, Douglas E.
Publicado em 2012

Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite

Por Pejo, Ervin, Liu, Jifeng, Lin, Xiangjie, Raines, Douglas E.
Publicado no Anesth Analg (2016)

Sedative-Hypnotic Binding to 11β-Hydroxylase

Por Pejo, Ervin, Zhou, Xiaojuan, Husain, S. Shaukat, Raines, Douglas E.
Publicado no Anesthesiology (2016)

Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate

Por Ge, Rile, Pejo, Ervin, Cotten, Joseph F, Raines, Douglas E
Publicado em 2013

Carboetomidate Inhibits Alpha4/Beta2 Neuronal Nicotinic Acetylcholine Receptors at Concentrations Affecting Animals

Por Pierce, David W., Pejo, Ervin, Raines, Douglas E., Forman, Stuart A.
Publicado em 2012

Electroencephalographic and Hypnotic Recoveries Following Brief and Prolonged Infusions of Etomidate and Optimized Soft Etomidate Analogs

Por Ge, Rile, Pejo, Ervin, Husain, S. Shaukat, Cotten, Joseph F., Raines, Douglas E.
Publicado em 2012

Analogues of Etomidate: Modifications Around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

Por Pejo, Ervin, Santer, Peter, Jeffrey, Spencer, Gallin, Hilary, Husain, S. Shaukat, Raines, Douglas E.
Publicado em 2014

GABA(A) Receptor Modulation by Etomidate Analogues

Por Pejo, Ervin, Santer, Peter, Wang, Lei, Dershwitz, Philip, Husain, S. Shaukat, Raines, Douglas E.
Publicado no Anesthesiology (2016)

Electroencephalographic Recovery, Hypnotic Emergence, and the Effects of Metabolite Following Continuous Infusions of a Rapidly Metabolized Etomidate Analog in Rats

Por Pejo, Ervin, Ge, Rile, Banacos, Natalie, Cotten, Joseph F., Husain, S. Shaukat, Raines, Douglas E.
Publicado em 2012

Differential Effects of Etomidate and its Pyrrole Analogue Carboetomidate on the Adrenocortical and Cytokine Responses to Endotoxemia

Por Pejo, Ervin, Feng, Yan, Chao, Wei, Cotten, Joseph F, Ge, Ri Le, Raines, Douglas E
Publicado em 2012

Pharmacological Studies of Methoxycarbonyl Etomidate's Carboxylic Acid Metabolite

Por Ge, Ri Le, Pejo, Ervin, Haburcak, Marian, Husain, S. Shaukat, Forman, Stuart A., Raines, Douglas E.
Publicado em 2011

Closed-loop Continuous Infusions of Etomidate and Etomidate Analogs in Rats: A Comparative Study of Dosing and the Impact on Adrenocortical Function

Por Cotten, Joseph F., Le Ge, Ri, Banacos, Natalie, Pejo, Ervin, Husain, S. Shaukat, Williams, James H., Raines, Douglas E.
Publicado em 2011

Azo-Propofols: Photochromic Potentiators of GABA(A) Receptors

Por Stein, Marco, Middendorp, Simon J., Carta, Valentina, Pejo, Ervin, Raines, Douglas E., Forman, Stuart A., Sigel, Erwin, Trauner, Dirk
Publicado em 2012

Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analogue with Low Intrinsic Efficacy

Por Ma, Celena, Pejo, Ervin, McGrath, Megan, Jayakar, Selwyn S., Zhou, Xiaojuan, Miller, Keith W, Cohen, Jonathan B., Raines, Douglas E.
Publicado no Anesthesiology (2017)

In Vivo and In Vitro Pharmacological Studies of Methoxycarbonyl-Carboetomidate

Por Pejo, Ervin, Cotten, Joseph F., Kelly, Elizabeth W., Ge, Ri Le, Cuny, Gregory D., Laha, Joydev K., Liu, Jifeng, Lin, Xiang Jie, Raines, Douglas E.
Publicado em 2011