Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor by [(3)H]Azietomidate, an Open-State Inhibitor

Azietomidate is a photoreactive analog of the general anesthetic etomidate that acts as a nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist. We used rapid perfusion electrophysiological techniques to characterize the state dependence and kinetics of azietomidate inhibition of Torped...

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Detalhes bibliográficos
Main Authors: Chiara, David C., Hong, Filbert H., Arevalo, Enrique, Husain, S. Shaukat, Miller, Keith W., Forman, Stuart A., Cohen, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672814/
https://ncbi.nlm.nih.gov/pubmed/19218367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.054353
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