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Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor by [(3)H]Azietomidate, an Open-State Inhibitor
Azietomidate is a photoreactive analog of the general anesthetic etomidate that acts as a nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist. We used rapid perfusion electrophysiological techniques to characterize the state dependence and kinetics of azietomidate inhibition of Torped...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2672814/ https://ncbi.nlm.nih.gov/pubmed/19218367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.054353 |
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