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Methoxycarbonyl-etomidate: A Novel Rapidly Metabolized and Ultra-Short Acting Etomidate Analogue That Does Not Produce Prolonged Adrenocortical Suppression

BACKGROUND: Etomidate is a rapidly-acting sedative-hypnotic that provides hemodynamic stability. However because it causes prolonged suppression of adrenocortical steroid synthesis, its clinical utility and safety are limited. We describe the results of studies to define the pharmacology of (R)-3-me...

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Main Authors: Cotten, Joseph F., Husain, S. Shaukat, Forman, Stuart A., Miller, Keith W., Kelly, Elizabeth W., Nguyen, Hieu H., Raines, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739411/
https://ncbi.nlm.nih.gov/pubmed/19625798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3181ae63d1
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