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Methoxycarbonyl-etomidate: A Novel Rapidly Metabolized and Ultra-Short Acting Etomidate Analogue That Does Not Produce Prolonged Adrenocortical Suppression

BACKGROUND: Etomidate is a rapidly-acting sedative-hypnotic that provides hemodynamic stability. However because it causes prolonged suppression of adrenocortical steroid synthesis, its clinical utility and safety are limited. We describe the results of studies to define the pharmacology of (R)-3-me...

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Autors principals: Cotten, Joseph F., Husain, S. Shaukat, Forman, Stuart A., Miller, Keith W., Kelly, Elizabeth W., Nguyen, Hieu H., Raines, Douglas E.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739411/
https://ncbi.nlm.nih.gov/pubmed/19625798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3181ae63d1
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