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The Kinetics of Anesthetic-induced Conformational Transitions in a Four-α-Helix Bundle Protein

Inhaled anesthetics are thought to alter the conformational states of Cys-loop ligand-gated ion channels (LGICs) by binding within discrete cavities that are lined by portions of four α-helical transmembrane domains. Because Cys-loop LGICs are complex molecules that are notoriously difficult to expr...

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Detalhes bibliográficos
Main Authors: Solt, Ken, Johansson, Jonas S., Raines, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581500/
https://ncbi.nlm.nih.gov/pubmed/16445285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052206o
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