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Four-α-Helix Bundle with Designed Anesthetic Binding Pockets. Part I: Structural and Dynamical Analyses

The four-α-helix bundle mimics the transmembrane domain of the Cys-loop receptor family believed to be the protein target for general anesthetics. Using high resolution NMR, we solved the structure (Protein Data Bank ID: 2I7U) of a prototypical dimeric four-α-helix bundle, (Aα(2)-L1M/L38M)(2,) with...

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Dettagli Bibliografici
Autori principali: Ma, Dejian, Brandon, Nicole R., Cui, Tanxing, Bondarenko, Vasyl, Canlas, Christian, Johansson, Jonas S., Tang, Pei, Xu, Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480675/
https://ncbi.nlm.nih.gov/pubmed/18310240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.117838
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