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Four-α-Helix Bundle with Designed Anesthetic Binding Pockets. Part I: Structural and Dynamical Analyses
The four-α-helix bundle mimics the transmembrane domain of the Cys-loop receptor family believed to be the protein target for general anesthetics. Using high resolution NMR, we solved the structure (Protein Data Bank ID: 2I7U) of a prototypical dimeric four-α-helix bundle, (Aα(2)-L1M/L38M)(2,) with...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2480675/ https://ncbi.nlm.nih.gov/pubmed/18310240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.117838 |
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