Four-α-Helix Bundle with Designed Anesthetic Binding Pockets. Part II: Halothane Effects on Structure and Dynamics

As a model of the protein targets for volatile anesthetics, the dimeric four-α-helix bundle, (Aα(2)-L1M/L38M)(2), was designed to contain a long hydrophobic core, enclosed by four amphipathic α-helices, for specific anesthetic binding. The structural and dynamical analyses of (Aα(2)-L1M/L38M)(2) in...

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Detalhes bibliográficos
Main Authors: Cui, Tanxing, Bondarenko, Vasyl, Ma, Dejian, Canlas, Christian, Brandon, Nicole R., Johansson, Jonas S., Xu, Yan, Tang, Pei
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480694/
https://ncbi.nlm.nih.gov/pubmed/18310239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.117853
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