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Four-α-Helix Bundle with Designed Anesthetic Binding Pockets. Part II: Halothane Effects on Structure and Dynamics
As a model of the protein targets for volatile anesthetics, the dimeric four-α-helix bundle, (Aα(2)-L1M/L38M)(2), was designed to contain a long hydrophobic core, enclosed by four amphipathic α-helices, for specific anesthetic binding. The structural and dynamical analyses of (Aα(2)-L1M/L38M)(2) in...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2480694/ https://ncbi.nlm.nih.gov/pubmed/18310239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.117853 |
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