Glucocorticoids and Cancer

Por Pufall, Miles A.
Publicado no Adv Exp Med Biol (2015)

Mechanisms of eukaryotic transcription

Por Pufall, Miles A, Kaplan, Craig D
Publicado em 2013

Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death

Por Poulard, Coralie, Baulu, Estelle, Lee, Brian H., Pufall, Miles A., Stallcup, Michael R.
Publicado no Cell Death Dis (2018)

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

Por Meijsing, Sebastiaan H., Pufall, Miles A., So, Alex Y., Bates, Darren L., Chen, Lin, Yamamoto, Keith R.
Publicado em 2009

JUNB is a Key Transcriptional Modulator of Macrophage Activation

Por Fontana, Mary F., Baccarella, Alyssa, Pancholi, Nidhi, Pufall, Miles A., Herbert, De’Broski R., Kim, Charles C.
Publicado no J Immunol (2014)

Systematic in vitro profiling of off-target affinity, cleavage and efficiency for CRISPR enzymes

Por Zhang, Liyang, Rube, H Tomas, Vakulskas, Christopher A, Behlke, Mark A, Bussemaker, Harmen J, Pufall, Miles A
Publicado no Nucleic Acids Res (2020)

The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals

Por Watson, Lisa C., Kuchenbecker, Kristopher M., Schiller, Benjamin J., Gross, John D., Pufall, Miles A., Yamamoto, Keith R.
Publicado em 2013

Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids

Por Shipp, Lauren E., Lee, Joyce V., Yu, Chi-Yi, Pufall, Miles, Zhang, Pili, Scott, Donald K., Wang, Jen-Chywan
Publicado em 2010

The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region

Por Lee, Gregory M., Pufall, Miles A., Meeker, Charles A., Kang, Hyun-Seo, Graves, Barbara J., McIntosh, Lawrence P.
Publicado no J Mol Biol (2008)

Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain Inhibitor Pyrvinium

Por Pal, Sumanta K., Tew, Ben Yi, Lim, Minyoung, Stankavich, Brittany, He, Miaoling, Pufall, Miles, Hu, Weidong, Chen, Yuan, Jones, Jeremy O.
Publicado no ACS Omega (2019)

The Molecular Basis of Specific DNA Binding by the BRG1 AT-hook and Bromodomain

Por Sanchez, Julio C., Zhang, Liyang, Evoli, Stefania, Schnicker, Nicholas J., Nunez-Hernandez, Maria, Yu, Liping, Wereszczynski, Jeff, Pufall, Miles A., Musselman, Catherine A.
Publicado no Biochim Biophys Acta Gene Regul Mech (2020)

A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms

Por Thomas-Chollier, Morgane, Watson, Lisa C., Cooper, Samantha B., Pufall, Miles A., Liu, Jennifer S., Borzym, Katja, Vingron, Martin, Yamamoto, Keith R., Meijsing, Sebastiaan H.
Publicado em 2013

Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops

Por Sasse, Sarah K., Zuo, Zheng, Kadiyala, Vineela, Zhang, Liyang, Pufall, Miles A., Jain, Mukesh K., Phang, Tzu L., Stormo, Gary D., Gerber, Anthony N.
Publicado no J Biol Chem (2015)

Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression

Por Sasse, Sarah K., Gruca, Margaret, Allen, Mary A., Kadiyala, Vineela, Song, Tengyao, Gally, Fabienne, Gupta, Arnav, Pufall, Miles A., Dowell, Robin D., Gerber, Anthony N.
Publicado no Genome Res (2019)

Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes

Por Michaelson, Jacob J., Shin, Min-Kyoo, Koh, Jin-Young, Brueggeman, Leo, Zhang, Angela, Katzman, Aaron, McDaniel, Latisha, Fang, Mimi, Pufall, Miles, Pieper, Andrew A.
Publicado no Biol Psychiatry (2017)

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

Por Serafimova, Iana M., Pufall, Miles A., Krishnan, Shyam, Duda, Katarzyna, Cohen, Michael S., Maglathlin, Rebecca L., McFarland, Jesse M., Miller, Rand M., Frödin, Morten, Taunton, Jack
Publicado em 2012

SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site

Por Zhang, Liyang, Martini, Gabriella D., Rube, H. Tomas, Kribelbauer, Judith F., Rastogi, Chaitanya, FitzPatrick, Vincent D., Houtman, Jon C., Bussemaker, Harmen J., Pufall, Miles A.
Publicado no Genome Res (2018)

Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia

Por Poulard, Coralie, Kim, Hye Na, Fang, Mimi, Kruth, Karina, Gagnieux, Celine, Gerke, Daniel S., Bhojwani, Deepa, Kim, Yong-Mi, Kampmann, Martin, Stallcup, Michael R., Pufall, Miles A.
Publicado no Proc Natl Acad Sci U S A (2019)

Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages

Por Rollins, David A., Kharlyngdoh, Joubert B., Coppo, Maddalena, Tharmalingam, Bowranigan, Mimouna, Sanda, Guo, Ziyi, Sacta, Maria A., Pufall, Miles A., Fisher, Robert P., Hu, Xiaoyu, Chinenov, Yurii, Rogatsky, Inez
Publicado no Nat Commun (2017)

Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy

Por Bongers, Kale S., Fox, Daniel K., Kunkel, Steven D., Stebounova, Larissa V., Murry, Daryl J., Pufall, Miles A., Ebert, Scott M., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Adams, Christopher M.
Publicado no Am J Physiol Endocrinol Metab (2014)