The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region

Binding of the transcription factor Ets-1 to DNA is allosterically regulated by a serine rich region (SRR) that modulates the dynamic character of the adjacent structured DNA-binding ETS domain and its flanking autoinhibitory elements. Multi-site phosphorylation of the flexible SRR in response to Ca...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Lee, Gregory M., Pufall, Miles A., Meeker, Charles A., Kang, Hyun-Seo, Graves, Barbara J., McIntosh, Lawrence P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808631/
https://ncbi.nlm.nih.gov/pubmed/18692067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.07.064
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