Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor

The E26 transformation-specific (Ets-1) transcription factor is autoinhibited by a conformationally disordered serine-rich region (SRR) that transiently interacts with its DNA-binding ETS domain. In response to calcium signaling, autoinhibition is reinforced by calmodulin-dependent kinase II phospho...

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Main Authors: Desjardins, Geneviève, Meeker, Charles A., Bhachech, Niraja, Currie, Simon L., Okon, Mark, Graves, Barbara J., McIntosh, Lawrence P.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121781/
https://ncbi.nlm.nih.gov/pubmed/25024220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401891111
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