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Conformational Dynamics and the Binding of Specific and Nonspecific DNA by the Autoinhibited Transcription Factor Ets-1
The affinity of the Ets-1 transcription factor for DNA is autoinhibited by an intrinsically disordered serine-rich region (SRR) and a helical inhibitory module (IM) appended to its winged helix–turn–helix ETS domain. Using NMR spectroscopy, we investigated how Ets-1 recognizes specific versus nonspe...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568661/ https://ncbi.nlm.nih.gov/pubmed/27362745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00460 |
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