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DNA Binding by the ETS Protein TEL (ETV6) Is Regulated by Autoinhibition and Self-association
The ETS protein TEL, a transcriptional repressor, contains a PNT domain that, as an isolated fragment in vitro, self-associates to form a head-to-tail polymer. How such polymerization might affect the DNA-binding properties of full-length TEL is unclear. Here we report that monomeric TEL binds to a...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881775/ https://ncbi.nlm.nih.gov/pubmed/20400516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096958 |
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