Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5

Autoinhibition enables spatial and temporal regulation of cellular processes by coupling protein activity to surrounding conditions, often via protein partnerships or signaling pathways. We report the molecular basis of DNA-binding autoinhibition of ETS transcription factors ETV1, ETV4 and ETV5, whi...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Currie, Simon L., Lau, Desmond K. W., Doane, Jedediah J., Whitby, Frank G., Okon, Mark, McIntosh, Lawrence P., Graves, Barbara J.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
NAR Breakthrough Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389675/
https://ncbi.nlm.nih.gov/pubmed/28161714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx068
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