Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5

Autoinhibition enables spatial and temporal regulation of cellular processes by coupling protein activity to surrounding conditions, often via protein partnerships or signaling pathways. We report the molecular basis of DNA-binding autoinhibition of ETS transcription factors ETV1, ETV4 and ETV5, whi...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Currie, Simon L., Lau, Desmond K. W., Doane, Jedediah J., Whitby, Frank G., Okon, Mark, McIntosh, Lawrence P., Graves, Barbara J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
NAR Breakthrough Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389675/
https://ncbi.nlm.nih.gov/pubmed/28161714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx068
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