Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5

Autoinhibition enables spatial and temporal regulation of cellular processes by coupling protein activity to surrounding conditions, often via protein partnerships or signaling pathways. We report the molecular basis of DNA-binding autoinhibition of ETS transcription factors ETV1, ETV4 and ETV5, whi...

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Publicat a:Nucleic Acids Res
Autors principals: Currie, Simon L., Lau, Desmond K. W., Doane, Jedediah J., Whitby, Frank G., Okon, Mark, McIntosh, Lawrence P., Graves, Barbara J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
NAR Breakthrough Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389675/
https://ncbi.nlm.nih.gov/pubmed/28161714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx068
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