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Auto-inhibition of ETV6 (TEL) DNA-binding: appended helices sterically block the ETS domain
ETV6 (or TEL), a transcriptional repressor belonging to the ETS family, is frequently involved in chromosomal translocations linked with human cancers. It displays a DNA-binding mode distinct from other ETS proteins due to the presence of a self-associating PNT domain. In this study, we used NMR spe...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392548/ https://ncbi.nlm.nih.gov/pubmed/22584210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.05.010 |
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