Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP

Ras/MAPK signaling is often aberrantly activated in human cancers. The downstream effectors are transcription factors, including those encoded by the ETS gene family. Using cell-based assays and biophysical measurements, we have determined the mechanism by which Ras/MAPK signaling affects the functi...

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Главные авторы: Nelson, Mary L., Kang, Hyun-Seo, Lee, Gregory M., Blaszczak, Adam G., Lau, Desmond K. W., McIntosh, Lawrence P., Graves, Barbara J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890480/
https://ncbi.nlm.nih.gov/pubmed/20534573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915137107
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