P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

Por Pieper, Andrew A., McKnight, Steven L., Ready, Joseph M.
Publicado no Chem Soc Rev (2014)

Cacna1c: Protecting young hippocampal neurons in the adult brain

Por De Jesús-Cortés, Héctor, Rajadhyaksha, Anjali M., Pieper, Andrew A.
Publicado no Neurogenesis (Austin) (2016)

Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds

Por Voorhees, Jaymie R., Rohlman, Diane S., Lein, Pamela J., Pieper, Andrew A.
Publicado no Front Neurosci (2017)

Neuroprotective Efficacy of a Proneurogenic Compound after Traumatic Brain Injury

Por Blaya, Meghan O., Bramlett, Helen M., Naidoo, Jacinth, Pieper, Andrew A., Dietrich, W. Dalton
Publicado em 2014

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

Por Pieper, Andrew A., Brat, Daniel J., Krug, David K., Watkins, Crystal C., Gupta, Alok, Blackshaw, Seth, Verma, Ajay, Wang, Zhao-Qi, Snyder, Solomon H.
Publicado em 1999

P7C3 Neuroprotective Chemicals Function by Activating the Rate-limiting Enzyme in NAD Salvage

Por Wang, Gelin, Han, Ting, Nijhawan, Deepak, Theodoropoulos, Pano, Naidoo, Jacinth, Yadavalli, Sivaramakrishnan, Mirzaei, Hamid, Pieper, Andrew A., Ready, Joseph M., McKnight, Steven L.
Publicado em 2014

The Eating-Disorder Associated HDAC4(A778T) Mutation Alters Feeding Behaviors in Female Mice

Por Lutter, Michael, Khan, Michael Z., Satio, Kenji, Davis, Kevin C., Kidder, Ian J., McDaniel, Latisha, Darbro, Benjamin W., Pieper, Andrew A., Cui, Huxing
Publicado no Biol Psychiatry (2016)

Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

Por Naidoo, Jacinth, De Jesus-Cortes, Hector, Huntington, Paula, Estill, Sandi, Morlock, Lorraine K., Starwalt, Ruth, Mangano, Thomas J., Williams, Noelle S., Pieper, Andrew A., Ready, Joseph M.
Publicado em 2014

Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

Por Aqul, Amal, Liu, Benny, Ramirez, Charina M., Pieper, Andrew A., Estill, Sandi Jo, Burns, Dennis K., Liu, Bing, Repa, Joyce J., Turley, Stephen D., Dietschy, John M.
Publicado em 2011

Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice

Por Cui, Huxing, Lu, Yuan, Khan, Michael Z., Anderson, Rachel M., McDaniel, Latisha, Wilson, Hannah E., Yin, Terry C., Radley, Jason J., Pieper, Andrew A., Lutter, Michael
Publicado no Cell Rep (2015)

Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate–nitric oxide neurotransmission

Por Pieper, Andrew A., Blackshaw, Seth, Clements, Emily E., Brat, Daniel J., Krug, David K., White, Alison J., Pinto-Garcia, Patricia, Favit, Antonella, Conover, Jill R., Snyder, Solomon H., Verma, Ajay
Publicado em 2000

Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice

Por Yin, Terry C., Voorhees, Jaymie R., Genova, Rachel M., Davis, Kevin C., Madison, Ashley M., Britt, Jeremiah K., Cintrón-Pérez, Coral J., McDaniel, Latisha, Harper, Matthew M., Pieper, Andrew A.
Publicado no eNeuro (2016)

The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice

Por Pieper, Andrew A., Wu, Xinle, Han, Tina W., Estill, Sandi Jo, Dang, Quyen, Wu, Leeju C., Reece-Fincanon, Sarah, Dudley, Carol A., Richardson, James A., Brat, Daniel J., McKnight, Steven L.
Publicado em 2005

A suppressor screen in mouse Mecp2 implicates cholesterol metabolism in Rett Syndrome

Por Buchovecky, Christie M., Turley, Stephen D., Brown, Hannah M., Kyle, Stephanie M., McDonald, Jeffrey G., Liu, Benny, Pieper, Andrew A., Huang, Wenhui, Katz, David M., Russell, David W., Shendure, Jay, Justice, Monica J.
Publicado em 2013

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons123

Por Lee, Anni S., De Jesús-Cortés, Héctor, Kabir, Zeeba D., Knobbe, Whitney, Orr, Madeline, Burgdorf, Caitlin, Huntington, Paula, McDaniel, Latisha, Britt, Jeremiah K., Hoffmann, Franz, Brat, Daniel J., Rajadhyaksha, Anjali M., Pieper, Andrew A.
Publicado no eNeuro (2016)

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations

Por Cui, Huxing, Moore, Jarrette, Ashimi, Sunbola S., Mason, Brittany L., Drawbridge, Jordan N., Han, Shizhong, Hing, Benjamin, Matthews, Abigail, McAdams, Carrie J., Darbro, Benjamin W., Pieper, Andrew A., Waller, David A., Xing, Chao, Lutter, Michael
Publicado em 2013

NPAS1 Represses the Generation of Specific Subtypes of Cortical Interneurons

Por Stanco, Amelia, Pla, Ramón, Vogt, Daniel, Chen, Yiran, Mandal, Shyamali, Walker, Jamie, Hunt, Robert F., Lindtner, Susan, Erdman, Carolyn A., Pieper, Andrew A., Hamilton, Steven P., Xu, Duan, Baraban, Scott C., Rubenstein, John L. R.
Publicado no Neuron (2014)

Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice

Por Xu, Pin, Grueter, Brad A., Britt, Jeremiah K., McDaniel, Latisha, Huntington, Paula J., Hodge, Rachel, Tran, Stephanie, Mason, Brittany L., Lee, Charlotte, Vong, Linh, Lowell, Bradford B., Malenka, Robert C., Lutter, Michael, Pieper, Andrew A.
Publicado em 2013

Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease

Por De Jesús-Cortés, Héctor, Miller, Adam D, Britt, Jeremiah K, DeMarco, Anthony J, De Jesús-Cortés, Mayralis, Stuebing, Emily, Naidoo, Jacinth, Vázquez-Rosa, Edwin, Morlock, Lorraine, Williams, Noelle S, Ready, Joseph M, Narayanan, Nandakumar S, Pieper, Andrew A
Publicado no NPJ Parkinsons Dis (2015)

Development of proneurogenic, neuroprotective small molecules

Por MacMillan, Karen S., Naidoo, Jacinth, Liang, Jue, Melito, Lisa, Williams, Noelle S., Morlock, Lorraine, Huntington, Paula J., Estill, Sandi Jo, Longgood, Jamie, Becker, Ginger L., McKnight, Steven L., Pieper, Andrew A., De Brabander, Jef K., Ready, Joseph M.
Publicado em 2011